Abstract: The construction of a lunar scientific research station is an inevitable mean for carring out in-depth lunar scientific exploration and realizing the large-scale development and utilization of lunar resources. Restricted by the depth of human cognition of the Moon and the development level of existing space technology, the implementation of the task of building a lunar scientific research station still faces many technical difficulties. At present, with the in-depth research of artificial intelligence technology and the rapid development of its integrated application in various fields, new ideas have been brought to solve the above technical problems. In the paper the construction concept, system composition, mission characteristics and technical challenges faced by the lunar scientific research station were analyzed. On this basis, artificial intelligence technologies such as intelligent fusion perception, collaborative control, path planning, fault detection, decision planning and human-computer interaction etc. in these typical application scenarios were discussed, which will provide reference for the implementation of for the construction of lunar scientific research stations and manned Moon landing missions.