Abstract: Queqiao-2 faces key challenges including long-duration Earth shadow, intense radiation, extreme temperature fluctuations, antenna shading, weight constraints, and multi-payload safety. A highly reliable and intelligent power supply and distribution scheme was proposed. A Fully Regulated Bus（FRB）topology was adopted to achieve efficient and stable energy supply, an intelligent power distribution and hierarchical protection architecture was constructed to enhance bus safety and disturbance rejection capability; a redundant fault-tolerant control circuit for pyrotechnic devices was designed to ensure reliable execution of critical actions, and an autonomous battery life-cycle management strategy was established to achieve long-life on-orbit operation. Ground simulation and test verification, along with in-orbit operation data, indicate that indicators such as system power supply capability and battery depth of discharge meet the design requirements, and the operation is stable and reliable. This research can provide an important technical reference for the design of power supply and distribution systems for deep-space exploration spacecraft.