Abstract: In the face of the challenges of the extreme environment on Mars, this paper systematically combed the key considerations of Mars base siting, analyzed the distribution and availability of in-situ resources on Mars, such as water-ice, minerals, atmosphere, energy, etc., and discussed in detail the siting strategies for Mars impact craters, canyons and grooves, plains and highlands based on a comprehensive assessment of engineering elements related to base construction, such as landing buffer technology, terrain survey technology and construction, operation and maintenance technology. Drawing on the rich data accumulated by Mars exploration missions in recent years, the environmental characteristics of alternative landing zones were summarized in depth, providing multi-dimensional referrence for base site selection. At the same time, the limitations and future development direction of Mars base siting for in-situ resource utilization were accordingly pointed out, in hope of providing reference for future Mars base siting planning.