Abstract: Based on the working mode of the autonomous navigation guidance and control system of the impactor, the autonomous optical information processing algorithm, autonomous optical navigation algorithm and trajectory correction guidance law were designed. Based on the research work of autonomous navigation guidance and control system, a comprehensive test system of autonomous navigation guidance and control for small body impact detection was built. Semi-physical ground simulation test of autonomous navigation guidance and control for small body impact was carried out. The simulation results show that the proposed method can effectively achieve high precision asteroid impact.