Abstract: Regarding the layout design of micro thrusters for space gravitational wave detection satellites, a feasibility analysis of the layout of micro-thrusters were first presented, and then a robust optimization design method for the layout of micro-thrusters for space gravitational wave detection satellites was proposed. To obtain the robust optimization design results of the micro-thruster group layout of the space gravitational wave detection satellite, taking the condition number of the configuration matrix as evaluation standard, the thruster configuration with the strongest robustness to the configuration error was optimized through numerical simulation. The proposed method was applied to the layout design of micro-thrusters for space gravitational wave detection satellites. Simulation results show that it can improve the robustness of the layout scheme of micro-thrusters.