Abstract: Asteroid impact poses a major threat to human survival. High-speed direct impact is a feasible and effective means to change the orbit of an asteroid. This paper takes Bennu, a potentially hazardous asteroid, as an object to design the terminal guidance law of deep space high-speed impact. In view of the characteristics of high relative speed and high impact accuracy, the acceleration command is derived based on the Augmented Proportional Navigation Guidance law (APNG), considering the acceleration of the target. Moreover, the proportional coefficient is designed as a function of the relative distance to meet both the requirements of minimum fuel consumption and maximum impact accuracy. An ignition strategy is designed to convert the continuous command into impulse command, without the need to give maneuvering time in advance. The simulation results show the effectiveness of the proposed algorithm. The miss distance constraint is satisfied, and the ignition times and fuel consumption are less than those of the constant proportional coefficient algorithm.