Abstract: To reduce the total cost and risk of asteroid exploration,it is necessary to select multi-objective to avoid the disadvantages such as single target,high-cost and long-period. In this paper,a multi-target transfer trajectory design method is proposed based on the cubesats with the cooperation of gravity flyby and invariant manifolds. Introduced by the perturbation invariant manifolds,the cubesat can rapidly transfer to the target and carry out a global launch chance searching for asgteroids based on the Sun-Earth Halo parking orbit and determine the next target. The results indicated that the proposed method is able to significantly reduce the fuel consumption of trajectory transfer as well as transfer time.