Abstract: Based on the pointing accuracy requirements of large-caliber antennas equipped with deep-space detectors, a calibration scheme for the in-orbit pointing of deep-space detectors with large-diameter antennas is presented to solve the in-orbit pointing evaluation problem of large-caliber antennas. By analyzing the characteristics and constraints of the spacecraft,combining with the specific situation of the relaying satellite antenna of Chang'e-4,and adopting the method of satellite-Earth cooperative work,this paper presents the calibration scheme of the antenna pointing to the orbit,and the implementation process of the calibration. Finally,it gives the errors in the calibration process. This scheme can be applied to the design of calibration schemes for other large-space antenna large-caliber antennas.