Abstract: Graphical user interface(GUI)is crucial for astronaut's on-orbit operation in manned spacecraft. Given that the massive and mutable technical requirements of the human-computer interaction, and the long development period and severe technical difficulties , the design methods based on MiniGUI control are categorized and analyzed firstly. After that, based on above information, a customized design method is presented, which can add configurable attributes for users. Finally, the results of practical applications demonstrate that the display effect is enhanced dramatically and the design efficiency is improved considerably.