Abstract: The Moon is the nearest neighbor of the Earth and the first planet for human deep space exploration. Thus, the construction of long-term lunar research station will be great significant to further explore the deep space in 21st century. Mare Smythii is located at the junction of the lunar farside and nearside, and it is rich in the geological diversities and scientific values. In this paper, combined with the SLDEM 2015 elevation data, Clementine UV/VIS data, Kaguya MI data, and Chang'E-2 microwave radiometer data, the geological significance, topography, material composition, and microwave thermal emission features of Mare Smythii are thoroughly analyzed. Then, the region centered at (88^oE, 1^oN) is proposed for constructing the long-term lunar research station with high priority from the perspectives of scientific research, resources, and energy. Finally, three routes are outlined according to the surface topography, and 14 candidate exploring sites are planned aiming to scientific studies and resource utilizations. This study is of essential significance for the construction of the long term lunar research stations in future.