Abstract: The guidance,navigation and control system,the restrict condition of cruise trajectory,the control strategy design and its implementation process of the recent U.S. Mars landing mission,Mars Science Laboratory,are introduced.Then the experience of cruise navigation,guidance and control is analyzed and summarized.This paper has some reference to future Mars exploration mission of China.Some suggestions including establishing strictflight path control strategy by Monte Carlo method,studying non-gravitation effect,fining various fault scenario,choosing appropriate injection aim point,and increasing the space measurement and control station abroad.