Abstract: The terrain uncertainty and hazard such as surface roughness and slope will threaten the safety of soft landing. A pinpoint autonomous navigation and hazard avoidance method for lunar soft landing is proposed in this paper,which is composed of the autonomous navigation algorithm based on range-velocity-updated inertial navigation, the algorithm of hazard detection and targeted landing site selection, the relative navigation algorithm to the targeted landing site, and the relative hazard avoidance control algorithm. The method can be used to reduce the risk of safe landing and has been successfully used in the Chang' e-3 soft landing mission.