Abstract: As To meet the requirements of the Queqiao-2 relay communication payload for multiple deep-space exploration missions and relay communication services, a design method for comprehensive data processing and transmission with high performance, high integration, and high reliability was proposed. he research and development of key technologies such as front-end multi-source data scheduling and management, on-board reconfiguration and minimal system design, and wear leveling of large-capacity solid-state storage have been mainly completed. Through ground testing and on-orbit verification, this system has realized relay communication services between multiple lunar mission spacecraft and ground stations, as well as deep space exploration storage-computing-control integrated technology exceeding 8 Gb/s. It supports software on-orbit reconfiguration, and for the first time achieves a downlink data rate to Earth covering the range of 1–500 Mb/s. Moreover, it effectively supported the successful implementation of the world's first sampling return mission from the far side of the Moon—China's Chang'e-6 mission. This work can provide a reference for data processing and transmission design in future deep space exploration missions.