Abstract: In response to the TT&C (Tracking, Telemetry, and Command) and communication needs of China's future lunar communication, navigation, and remote sensing integrated constellation serving users in Earth–Moon space, accuracy and applicability of various orbit determination technologies were comprehensively analyzed, including ground-based orbit determination, GNSS signal leakage orbit determination, BeiDou inter-satellite link orbit determination, LiAISON autonomous orbit determination, ground-assisted GNSS orbit determination, and lunar laser ranging orbit determination. The feasibility of communication methods for supporting the constellation, such as direct Earth-based Ka-band/laser communication and Ka-band/laser relayed communication was analyzed. Based on this, technical solutions are proposed to support the TT&C and communication of China's integrated constellation, providing technical support for the design and implementation of its TT&C system.