Abstract: To address the communication requirements among multiple spacecraft in Queqiao communication, navigation and remote sensing constellation system, and to tackle the challenges existing in deep space communication, such as long communication delays, frequent link interruptions and non-uniform protocols, an integrated cross-domain network topology architecture, consisting of ground networks, geostationary orbit networks, lunar surface networks, lunar orbit networks, planetary surface networks and planetary orbit networks, and a layered network protocol architecture integrating CCSDS, ECSS, and IETF protocol systems were proposed, achieving unified protocol configuration for inter-spacecraft, spacecraft-to-ground and intra-spacecraft communications. Simulation experiments of the cislunar space link have shown that the BP/LTP protocol achieved an effective throughput of over 90% in high-latency and high-packet-loss deep space communication environments, significantly outperforming TCP, QUIC and CFDP protocols. Finally, prospects for key technologies related to the integrated networking of constellation systems, such as architecture design and verification, network information services, high-reliability transmission and intelligent and efficient routing, were discussed. This study can provide technical support for future network system construction of the Queqiao communication, navigation and remote sensing constellation system and has significant engineering implications.