Abstract: To deal with the difficulties of complex return flight process, complex coordinated control of four-explorers multi-combination modalities, related combination of multiple constraints and a variety of key intensive controls, a multi-objective collaborative planning for lunar sampling return was proposed in order to ensure that the intensive command arrangement of the multiple objectives and the various types of TT&C resources were coordinated and ordered. In this paper, the inheritance difference between the lunar sampling return and the previous lunar soft landing and near-Earth rendezvous and docking missions was analyzed. A description method of the uplink control relationship between complex multi-objective devices, a multi-objectives measurement and control resource allocation method and a multi-objectives event planning method were designed. The flight control application of Chang’E 5 on-orbit mission shows that the design is reasonable and feasible.