Abstract: Half-ballistic reentry is one of the key links of deep space exploration mission. It is characterized by many key technologies, many design constrains, and difficulties in experimental verification. According to the idea of System Engineering, aiming at the re-entry and return mission of "Chang'E-5", the design of constraints, reentry corridor, aerodynamic shape and re-entry trajectory is carried out, the relationship between various design elements is clarified, and the design scheme of "Chang'E-5" re-entry system is put forward, and the reentry and return flight procedure and the design of key tasks are also described in this paper. After the actual flight of the reentry vehicle in orbit, it shows that the analysis and design idea of the reentry mission is accurate , which lays the foundation for the subsequent deep space reentry mission.