Abstract: According to the interferometric observation data of Jiamusi deep space station and Kashi deep space station of China deep space network during the mission of Chang'E-4 prober, the orbit determination accuracy of real-time data and post-correction data respectively combined with the USB data is analyzed. The difference between the Earth Moon transfer section and the precise orbit is 100 meters, and the difference between the ring moon section and the precise ephemeris is 10 meters. At the same time, the influences of VLBI data weight setting on the orbit accuracy is analyzed. In view of theChina deep space network in subsequent deep space missions such as Chang’E 5, a time-sharing acquisition mode is proposed to reduce the amount of VLBI data. The influence of this mode on orbit accuracy is analyzed by using the measured VLBI data of Chang’E 4 prober. The results show that the real-time data accuracy of China’s deep space network VLBI data has reached the accuracy of post-correction data, which can support the follow-up deep space exploration tasks in China. At the same time, for 2 to 3 hours per day of common viewing time of two stations, in the time-sharing acquisition mode, the total 20 minutes per day data and 1 minute acquisition step can ensure that the orbit accuracy does not decrease.