Abstract: The stress distribution and natural frequency changing of honey comb sand wich plate is proposed in this paper with thermal load, and the natural frequency of honey combs and wich plate is predicted according to the stress distribution. The simulation results show that the natural frequency of honey combs and wich plate with carbon fiber skin is essentially the same with thermal load, and the constraint effect to the frequency change is very small. The frequency of honey combs and wich plate with aluminum alloy skin with thermal load changes greatly when constraint form changes, and the frequency is essentially the same with a small amount of constraint, and the major constraint will cause the frequency decreasing dramatically.